Dr. Jasmin and the lab would like to thank the American Fibromyalgia Syndrome Association, Inc. (AFSA) for recently awarding a grant for a project to use transgenic mice to model fibromyalgia.
Dr. Jasmin has also received a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health (NIH) for a project entitled Noradrenergic Dysfunction: A Model of Fibromyalgia Pain.
Dr. Jasmin's work on FMS involves basic research into the neurological basis of FMS pain, and more specifically the role of the central nervous system. He is collaborating with several experts on fibromyalgia, including Dr. Daniel Clauw at Georgetown University and Dr. Alice Larson at the University of Minnesota, St. Paul.
Dr. Jasmin also participates in educational events for the patient community. He has most recently given a 3 hour lecture to fibromyalgia patients from the Fibromyalgia Association of the Greater Northeast (based in Philadelphia).

FMS and noradrenaline

Part of the difficulty in understanding FMS is that many different types of physiologic abnormalities have been identified in fibromyalgia and “allied” conditions, including disturbances in autonomic and neuroendocrine function, in addition to abnormal pain processing.

In FMS,there is a deficit in noradrenaline (Russell, 1992) and a reduced reduced endogenous pain inhibition (Kosek, 1996; Lautenbacher, 1997)

We are therefore modeling in the rat the biochemical anomalies encountered in the CNS of fibromyalgia patients, mainly the decreased central noradrenaline and increased central nerve growth factor.

Links to additional resources on fibromyalgia:

American Fibromyalgia Syndrome Association, Inc. (AFSA) - a non-profit organization dedicated to research, education and patient advocacy for fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). AFSA is the only charitable organization whose primary mission is to seed research in FMS and CFS

Fibromyalgia Network - provides educational materials on fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS).

Oregon Fibromyalgia Foundation (OFF)- written and maintained by researcher Robert M. Bennett, M.D at the Oregon Health Sciences University

National Fibromyalgia Research Association - dedicated to education, treatment, and finding a cure for fibromyalgia

 


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