and the lab would like to thank the American
Fibromyalgia Syndrome Association, Inc. (AFSA) for recently awarding
a grant for a project to use transgenic mice to model fibromyalgia.
FMS and noradrenaline
Part of the difficulty in understanding FMS is that many different types of physiologic abnormalities have been identified in fibromyalgia and allied conditions, including disturbances in autonomic and neuroendocrine function, in addition to abnormal pain processing.
is a deficit in noradrenaline (Russell, 1992) and a reduced reduced endogenous
pain inhibition (Kosek, 1996; Lautenbacher, 1997)
We are therefore modeling in the rat the biochemical anomalies encountered in the CNS of fibromyalgia patients, mainly the decreased central noradrenaline and increased central nerve growth factor.
Links to additional resources on fibromyalgia:
American Fibromyalgia Syndrome Association, Inc. (AFSA) - a non-profit organization dedicated to research, education and patient advocacy for fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). AFSA is the only charitable organization whose primary mission is to seed research in FMS and CFS
Fibromyalgia Network - provides educational materials on fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS).
Oregon Fibromyalgia Foundation (OFF)- written and maintained by researcher Robert M. Bennett, M.D at the Oregon Health Sciences University
National Fibromyalgia Research Association - dedicated to education, treatment, and finding a cure for fibromyalgia
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